Preserved functional specialization for spatial processing in the middle occipital gyrus of the early blind
Identifieur interne : 003596 ( Main/Exploration ); précédent : 003595; suivant : 003597Preserved functional specialization for spatial processing in the middle occipital gyrus of the early blind
Auteurs : Laurent A. Renier [États-Unis, Belgique] ; Irina Anurova [États-Unis, Finlande] ; Anne G. De Volder [Belgique] ; Synnöve Carlson [Finlande] ; John Vanmeter [États-Unis] ; Josef P. Rauschecker [États-Unis, Finlande]Source :
- Neuron [ 0896-6273 ] ; 2010.
Abstract
The occipital cortex (OC) of early-blind humans is activated during various nonvisual perceptual and cognitive tasks, but little is known about its modular organization. Using functional MRI we tested whether processing of auditory versus tactile and spatial versus nonspatial information was dissociated in the OC of the early blind. No modality-specific OC activation was observed. However, the right middle occipital gyrus (MOG) showed a preference for spatial over nonspatial processing of both auditory and tactile stimuli. Furthermore, MOG activity was correlated with accuracy of individual sound localization performance. In sighted controls, most of extrastriate OC, including the MOG, was de-activated during auditory and tactile conditions, but the right MOG was more activated during spatial than nonspatial visual tasks. Thus, although the sensory modalities driving the neurons in the reorganized OC of blind individuals are altered, the functional specialization of extrastriate cortex is retained regardless of visual experience.
Url:
DOI: 10.1016/j.neuron.2010.09.021
PubMed: 20920797
PubMed Central: 2951740
Affiliations:
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Renier</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory for Integrative Neuroscience and Cognition; Department of Physiology and Biophysics; Georgetown University; Medical Center; 3970 Reservoir Road, NW Washington, DC 20007, U.S.A.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory for Integrative Neuroscience and Cognition; Department of Physiology and Biophysics; Georgetown University; Medical Center; 3970 Reservoir Road, NW Washington, DC 20007</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Institute of Neuroscience; Université Catholique de Louvain; Avenue Hippocrate, 54, UCL-54.46, B-1200 Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Institute of Neuroscience; Université Catholique de Louvain; Avenue Hippocrate, 54, UCL-54.46, B-1200 Brussels</wicri:regionArea><wicri:noRegion>B-1200 Brussels</wicri:noRegion></affiliation></author><author><name sortKey="Anurova, Irina" sort="Anurova, Irina" uniqKey="Anurova I" first="Irina" last="Anurova">Irina Anurova</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory for Integrative Neuroscience and Cognition; Department of Physiology and Biophysics; Georgetown University; Medical Center; 3970 Reservoir Road, NW Washington, DC 20007, U.S.A.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory for Integrative Neuroscience and Cognition; Department of Physiology and Biophysics; Georgetown University; Medical Center; 3970 Reservoir Road, NW Washington, DC 20007</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Neuroscience Unit, Institute of Biomedicine/Physiology; University of Helsinki, 00014 Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Neuroscience Unit, Institute of Biomedicine/Physiology; University of Helsinki, 00014 Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="De Volder, Anne G" sort="De Volder, Anne G" uniqKey="De Volder A" first="Anne G." last="De Volder">Anne G. De Volder</name><affiliation wicri:level="1"><nlm:aff id="A2">Institute of Neuroscience; Université Catholique de Louvain; Avenue Hippocrate, 54, UCL-54.46, B-1200 Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Institute of Neuroscience; Université Catholique de Louvain; Avenue Hippocrate, 54, UCL-54.46, B-1200 Brussels</wicri:regionArea><wicri:noRegion>B-1200 Brussels</wicri:noRegion></affiliation></author><author><name sortKey="Carlson, Synnove" sort="Carlson, Synnove" uniqKey="Carlson S" first="Synnöve" last="Carlson">Synnöve Carlson</name><affiliation wicri:level="4"><nlm:aff id="A3">Neuroscience Unit, Institute of Biomedicine/Physiology; University of Helsinki, 00014 Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Neuroscience Unit, Institute of Biomedicine/Physiology; University of Helsinki, 00014 Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Brain Research Unit, Low Temperature Laboratory, Aalto University School of Science and Technology, FI-00076 AALTO, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Brain Research Unit, Low Temperature Laboratory, Aalto University School of Science and Technology, FI-00076 AALTO</wicri:regionArea><wicri:noRegion>FI-00076 AALTO</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Medical School, University of Tampere, 33014 Tampere, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical School, University of Tampere, 33014 Tampere</wicri:regionArea><wicri:noRegion>33014 Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Vanmeter, John" sort="Vanmeter, John" uniqKey="Vanmeter J" first="John" last="Vanmeter">John Vanmeter</name><affiliation wicri:level="1"><nlm:aff id="A6">Center for Functional and Molecular Imaging; Georgetown University Medical Center, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Functional and Molecular Imaging; Georgetown University Medical Center</wicri:regionArea></affiliation></author><author><name sortKey="Rauschecker, Josef P" sort="Rauschecker, Josef P" uniqKey="Rauschecker J" first="Josef P." last="Rauschecker">Josef P. Rauschecker</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory for Integrative Neuroscience and Cognition; Department of Physiology and Biophysics; Georgetown University; Medical Center; 3970 Reservoir Road, NW Washington, DC 20007, U.S.A.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory for Integrative Neuroscience and Cognition; Department of Physiology and Biophysics; Georgetown University; Medical Center; 3970 Reservoir Road, NW Washington, DC 20007</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Mind and Brain Laboratory, Centre of Excellence in Computational Complex Systems Research, Aalto University School of Science and Technology, FI-00076 AALTO, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Mind and Brain Laboratory, Centre of Excellence in Computational Complex Systems Research, Aalto University School of Science and Technology, FI-00076 AALTO</wicri:regionArea><wicri:noRegion>FI-00076 AALTO</wicri:noRegion></affiliation></author></analytic><series><title level="j">Neuron</title><idno type="ISSN">0896-6273</idno><idno type="eISSN">1097-4199</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p id="P1">The occipital cortex (OC) of early-blind humans is activated during various nonvisual perceptual and cognitive tasks, but little is known about its modular organization. Using functional MRI we tested whether processing of auditory versus tactile and spatial versus nonspatial information was dissociated in the OC of the early blind. No modality-specific OC activation was observed. However, the right middle occipital gyrus (MOG) showed a preference for spatial over nonspatial processing of both auditory and tactile stimuli. Furthermore, MOG activity was correlated with accuracy of individual sound localization performance. In sighted controls, most of extrastriate OC, including the MOG, was de-activated during auditory and tactile conditions, but the right MOG was more activated during spatial than nonspatial visual tasks. Thus, although the sensory modalities driving the neurons in the reorganized OC of blind individuals are altered, the functional specialization of extrastriate cortex is retained regardless of visual experience.</p></div></front></TEI><affiliations><list><country><li>Belgique</li><li>Finlande</li><li>États-Unis</li></country><region><li>District de Columbia</li><li>Uusimaa</li></region><settlement><li>Helsinki</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><country name="États-Unis"><region name="District de Columbia"><name sortKey="Renier, Laurent A" sort="Renier, Laurent A" uniqKey="Renier L" first="Laurent A." last="Renier">Laurent A. Renier</name></region><name sortKey="Anurova, Irina" sort="Anurova, Irina" uniqKey="Anurova I" first="Irina" last="Anurova">Irina Anurova</name><name sortKey="Rauschecker, Josef P" sort="Rauschecker, Josef P" uniqKey="Rauschecker J" first="Josef P." last="Rauschecker">Josef P. Rauschecker</name><name sortKey="Vanmeter, John" sort="Vanmeter, John" uniqKey="Vanmeter J" first="John" last="Vanmeter">John Vanmeter</name></country><country name="Belgique"><noRegion><name sortKey="Renier, Laurent A" sort="Renier, Laurent A" uniqKey="Renier L" first="Laurent A." last="Renier">Laurent A. Renier</name></noRegion><name sortKey="De Volder, Anne G" sort="De Volder, Anne G" uniqKey="De Volder A" first="Anne G." last="De Volder">Anne G. De Volder</name></country><country name="Finlande"><region name="Uusimaa"><name sortKey="Anurova, Irina" sort="Anurova, Irina" uniqKey="Anurova I" first="Irina" last="Anurova">Irina Anurova</name></region><name sortKey="Carlson, Synnove" sort="Carlson, Synnove" uniqKey="Carlson S" first="Synnöve" last="Carlson">Synnöve Carlson</name><name sortKey="Carlson, Synnove" sort="Carlson, Synnove" uniqKey="Carlson S" first="Synnöve" last="Carlson">Synnöve Carlson</name><name sortKey="Carlson, Synnove" sort="Carlson, Synnove" uniqKey="Carlson S" first="Synnöve" last="Carlson">Synnöve Carlson</name><name sortKey="Rauschecker, Josef P" sort="Rauschecker, Josef P" uniqKey="Rauschecker J" first="Josef P." last="Rauschecker">Josef P. Rauschecker</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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